Nottingham had the highest proportion of households without any adults in work in the UK last year, according to the Office for National Statistics (ONS).
More than a third (30.1%) of households including people aged 16-24 were jobless last year, up from a quarter (26.4%) a year earlier.
This is the first time that the city has ranked the highest since the ONS began in 2004.
The city has overtaken Glasgow, which had 29.8% of workless households last year. Liverpool and Wolverhampton also found themselves in the top five areas for households with no paid employment.
The ONS have claimed the increase was largely down to a rise in the number of people giving sickness or disability as a reason for not working. Other reasons included early retirement, study and looking after family members.